Reshaping the Endogenous Electric Field to Boost Wound Repair via Electrogenerative Dressing. Issue 16 (9th March 2023)

• Record Type: Journal Article
• Authors: Luo, Ruizeng; Liang, Yi; Yang, Jinrui; Feng, Hongqing; Chen, Ying; Jiang, Xupin; Zhang, Ze; Liu, Jie; Bai, Yuan; Xue, Jiangtao; Chao, Shengyu; Xi, Yi; Liu, Xiaoqiang; Wang, Engui; Luo, Dan; Li, Zhou; Zhang, Jiaping
• Is Part Of: Advanced materials. Volume 35:Issue 16(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-09
• Subjects: electric field therapy -- epithelial regeneration -- negative‐pressure wound therapy -- self‐powered electrical simulation dressings -- triboelectric nanogenerators; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202208395
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: The endogenous electric field (EF) generated by transepithelial potential difference plays a decisive role in wound reepithelialization. For patients with large or chronic wounds, negative‐pressure wound therapy (NPWT) is the most effective clinical method in inflammation control by continuously removing the necrotic tissues or infected substances, thus creating a proproliferative microenvironment beneficial for wound reepithelialization. However, continuous negative‐pressure drainage causes electrolyte loss and weakens the endogenous EF, which in turn hinders wound reepithelialization. Here, an electrogenerative dressing (EGD) is developed by integrating triboelectric nanogenerators with NPWT. By converting the negative‐pressure‐induced mechanical deformation into electricity, EGD produces a stable and high‐safety EF that can trigger a robust epithelial electrotactic response and drive the macrophages toward a reparative M2 phenotype in vitro. Translational medicine studies confirm that EGD completely reshapes the wound EF weakened by NPWT, and promotes wound closure by facilitating an earlier transition of inflammation/proliferation and guiding epithelial migration and proliferation to accelerate reepithelialization. Long‐term EGD therapy remarkably advances tissue remodeling with mature epithelium, orderly extracellular matrix, and less scar formation. Compared with the golden standard of NPWT, EGD orchestrates all the essential wound stages in a noninvasive manner, presenting an excellent prospect in clinical wound therapy. Abstract : A noninvasive electrogenerative dressing (EGD) is designed by integrating triboelectric nanogenerators with negative‐pressure wound therapy, which makes a great breakthrough in wound repair and scar prevention with clinical transformation potential. The EGD accelerates the polarization of macrophages to M2 macrophages, strengthens cell proliferation and migration, augments angiogenesis and reepithelialization, enhances orientation of collagen, and reduces scars.