Nanotechnology and photodynamic therapy from a clinical perspective. Issue 1 (27th November 2022)

• Record Type: Journal Article
• Authors: Abdel Gaber, Sara A.; Fadel, Maha
• Other Names: Lilge Lothar guestEditor.; Ruehm Adrian guestEditor.; Wang Xiuli guestEditor.
• Is Part Of: Translational biophotonics. Volume 5:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-27
• Subjects: clinical photodynamic therapy -- multimodal therapy -- nanotechnology -- targeting; Imaging systems in medicine -- Periodicals; Biosensors -- Optical properties -- Periodicals; Photonics -- Periodicals; Imaging systems in medicine; Photonics; Optics and Photonics; Translational Medical Research; Periodicals; Periodical; 621.365
• DOI: 10.1002/tbio.202200016
• Languages: English
• ISSNs: 2627-1850

Abstract

Abstract: Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Issues like hydrophobicity of the photosensitizer (PS), uncontrolled distribution and limited tissue penetration of the accompanying light sources triggered the interest of many research groups. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated. Abstract : Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated.