Development of Folate‐Superparamagnetic Nanoconjugates for Inhibition of Cancer Cell Proliferation. Issue 12 (22nd March 2023)

• Record Type: Journal Article
• Authors: Ferjaoui, Zied; Nahle, Sara; Schneider, Raphaël; Kerdjoudj, Halima; Mertz, Damien; Quilès, Fabienne; Ferji, Khalid; Gaffet, Eric; Alem, Halima
• Is Part Of: Advanced materials interfaces. Volume 10:Issue 12(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-22
• Subjects: cells targeting -- core/shell nanoparticles -- doxorubicin -- drug delivery -- folic acid -- hyperthermia -- magnetic nanoparticles -- responsive nanomaterials; Materials science -- Periodicals; 620.11
• DOI: 10.1002/admi.202202364
• Languages: English
• ISSNs: 2196-7350

Abstract

Abstract: Here, a versatile strategy to engineer smart theranostic nanocarriers is reported. The core/shell nanosystem is composed of a superparamagnetic iron oxide (Fe3− δ O4 ) nanoparticle (NP) core bearing the biocompatible thermo‐responsive poly(2‐(2‐methoxy)ethyl methacrylate‐oligo(ethylene glycol methacrylate), P(MEO2 MA x ‐OEGMA100− x ) copolymer (where x and 100‐ x represent the molar fractions of MEO2 MA and OEGMA, respectively). Folic acid (FA) is end‐conjugated to the P(MEO2 MA x ‐OEGMA100− x ) copolymer, leading to Fe3 − δ O4 @P(MEO2 MA x ‐OEGMA100− x )‐FA, to facilitate active targeting of NPs to cancer cells. A highly potent hydrophobic anticancer agent doxorubicin (DOX) is incorporated in the thermo‐responsive P(MEO2 MA x ‐OEGMA y ) brushes via supramolecular interactions to increase its solubility and the assessment of therapeutic potentials. These experiments confirm the magnetic hyperthermia properties of nanocarrier and reveal that only a small amount (10% ± 4%) of DOX is diffused at room temperature, while almost full drug (100%) is released after 52 h at 41 °C. Interestingly, it is found that P(MEO2 MA60 ‐OEGMA40 ) polymers offer to NPs a promising stealth behavior against Human Serum Albumin and Fibrinogen model proteins. Abstract : A versatile strategy to engineer smart theranostic nanocarriers displaying promising stealth behavior against Human model proteins is reported.