Cobalt‐Catalyzed Allylic Defluorinative Cross‐Electrophile Coupling between 1, 1‐Difluoroalkyl Halides and α‐Trifluoromethyl Styrenes. Issue 8 (4th April 2023)

• Record Type: Journal Article
• Authors: Dong, Haiyan; Lin, Zhiyang; Wang, Chuan
• Is Part Of: Advanced synthesis & catalysis. Volume 365:Issue 8(2023)
• Page Start: 1165
• Page End: 1169
• Publication Date: 2023-04-04
• Subjects: gem-Difluoroalkene -- gem-Difluoroalkane -- C−F Bond Cleavage -- Reductive Cross-Coupling -- Cobalt; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202300171
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: In this protocol, we apply reductive cobalt catalysis in the allylic defluorinative cross‐electrophile coupling reaction between 1, 1‐difluoroalkyl halides and α‐trifluoromethyl styrenes. This reaction features broad substrate scope (39 examples), good tolerance of various functionalities, and circumvention of pregenerating organometallics, offering a general synthetic route to prepare diverse organofluorines incorporating both a gem ‐difluoroalkene and a gem ‐difluoroalkane moiety. Abstract :