A Simple and Efficient Ligand-Free Copper-Catalyzed C-N Bond Formation of Aryl (Hetero) Halides and N-Heteroaryl Amines. (2nd January 2023)

• Record Type: Journal Article
• Authors: Kommuri, Venkata Chandrasekhar; Tadiparthi, Krishnaji; Pawar, Lokesh; Arunachalampillai, Athimoolam
• Is Part Of: Polycyclic aromatic compounds. Volume 43:Number 1(2023)
• Page Start: 665
• Page End: 673
• Publication Date: 2023-01-02
• Subjects: Ullman coupling -- ligand free -- CuI -- N-heteroaryl amines -- pyrimidines and pyrazines; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2021.2019802
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: In this protocol, we report a simple, inexpensive, and user-friendly conventional method for C-N cross coupling between aryl/heteroaryl halides and hetero aryl amines using copper iodide as a catalyst in DMSO as a solvent to prepare pyrimidines and pyrazines derivatives. The reaction conditions were optimized by screening in various copper catalysts and bases. The substrate scope of the reaction was also carried out to prepare novel functionalized N -arylated compounds in good yields. Graphical Abstract: UF0001