E0353 Peripheral pulse wave velocity as screening for subclinical vasculopathy in rheumatoid arthritis. (17th November 2010)

• Record Type: Journal Article
• Authors: Ting, Xu; Kamsang, Woo; Yongfei, Fang; Jing, Huang
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A110
• Page End: A110
• Publication Date: 2010-11-17
• Subjects: Rheumatoid arthritis -- arterial stiffness -- vasculopathy -- ultrasound; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.353
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: This study aims to evaluate a noninvasive method for screening of early vasculopathy in high risk patients suffering from rheumatoid arthritis (RA). Methods: Brachial-ankle pulse wave velocity (baPWV) was measured in RA group (n=132) and age, gender, height-matched healthy volunteers (n=132). Vasculitis specific biomarkers, biochemical and immune indices were recorded in RA patients. Multiple regression analysis was performed in RA group to determine the independent predictors of baPWV. Echo-tracking technique was used to measure pressure elastic coefficient (Eρ) and stiffness parameter (β) of brachial and posterior tibial artery in 25 RA patients and 48 matched controls. Results: The baPWV in RA group was significantly increased as compared with control group (15.0 [9.2–30.0] m/s versus 12.6 [9.6–16.0] m/s, respectively, p<0.0001). On multiple regression, baPWV correlated independently with age, heart rate, mean arterial pressure and perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) (R2adj=0.6868, p<0.0001; F=33.32, p<0.0001; power=85%; n=107). The Ep (477.9±138.1 versus 315.2±111.9 KPa; p<0.0001) and β (34.90±11.00 vs 24.99±7.81; p<0.0001) of posterior tibial artery in RA group were significantly higher than those in control group. There were no significant difference in Eρ and β of brachial artery between the two groups (p>0.05). Conclusions: There was a significant increase of baPWV, Ep and β of posterior tibial artery in RA group compared with control subjects, which related well to p-ANCA. BaPWV may provide a simple, noninvasive method for screening of early subclinical vasculopathy in RA patients.