Synthesis, crystal structure and antibacterial activity of zinc(II) complexes with Schiff bases derived from 5-fluorosalicylaldehyde. Issue 2 (17th January 2023)

• Record Type: Journal Article
• Authors: Liang, Xiao-Xue; Zhao, Xin-Yu; Guo, Ang; Wang, Xiao-Wen; Rong, Mei; Chang, Lin; Sun, Zhong-Qiao; Jin, Xu-Dong
• Is Part Of: Journal of coordination chemistry. Volume 76:Issue 2(2023)
• Page Start: 307
• Page End: 321
• Publication Date: 2023-01-17
• Subjects: 5-Fluorosalicylaldehyde -- Schiff base -- zinc(II) complex -- synthesis -- crystal structure; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2023.2170795
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: By a condensation of aliphatic amine containing adamantyl groups (amantadine, memantine, or 3-amino-1-adamantanol) and 5-fluorosalicylaldehyde, three new Schiff base ligands, HL 1 – 3, were synthesized. One Schiff base, zinc(II) chloride, and NaOH were stirred in anhydrous methanol generating three new zinc(II) complexes, C34 H38 F2 N2 O2 Zn (1 ), C38 H46 F2 N2 O2 Zn (2 ), and C34 H38 F2 N2 O4 Zn (3 ), respectively. These complexes were characterized by melting point, elemental analysis, infrared spectrum, ultraviolet–visible spectrum, 1 H NMR analysis, thermal analysis, and single-crystal X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that 1 and 3 crystallize in the monoclinic system with space group P2 1 /c, but 2 crystallizes in the orthorhombic system with space group Pbca . Each asymmetric unit in 1 is composed of one zinc(II) and two deprotonated ligands; each asymmetric unit in 2 is constituted of one zinc(II), two deprotonated ligands as well as one dichloromethane. Each asymmetric unit in 3 is made up of one zinc(II), two deprotonated ligands, one methanol, and one lattice water. The central zinc(II) in 1 –3 is four-coordinate via two nitrogen atoms and two oxygen atoms from the corresponding Schiff base ligands, forming a distorted tetrahedral geometry. The antibacterial activities of the three Schiff base ligands and the corresponding complexes against two gram positive bacteria, Staphylococcus aureus and Bacillus subtilis, and a gram negative bacteria, Escherichia coli, were tested. Abstract : UF0001