E0510 Relation between clopidogrel resistance and inflammation facor in patients after coronary stenting. (17th November 2010)

• Record Type: Journal Article
• Authors: Hailong, Ge; Yujie, Zhou; Yinxin, Zhao; Dongmei, Shi; Yuyang, Liu; Yonghe, Guo; Qing, Yang; Wanjun, Cheng
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A159
• Page End: A159
• Publication Date: 2010-11-17
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.510
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To observe the serum levels of inflammatory cytokines in patients with clopidogrel resistance underwent PCI. Methods: Platelet aggregation (PAG) induced with ADP were detected in 593 patients with unstable angina pectoris and had received coronary stenting. All patients were divided into clopidogrel resistance (CLR) group (n=333) and normal response group (n=260) according to PAG. At the same time, perpheral blood sample of all the patients were taken before, 24 h, 1 week and 1 month after implanting stents. The levels of C-reactive protein (CRP), P-selection and soluble fragment of CD40 ligand (sCD40L) in these patients were detected by enzyme linked immunosorbent assay. Results: The incidence of clopidogrel resistance in 24 h, 1 week and 1 month after PCI was 35.5%, 26.9% and 19.3%. The levels of CRP (8.8±2.5 mg/dl at 24 h, 5.3±2.5 mg/dl at 1 week), P-selection (73.8±34 ng/ml at 24 h, 70.5±31.6 ng/ml at 1 week and 66.4±22.3 ng/ml at 1 month) and sCD40L (7.7±2.3 ng/ml at 24 h)had significant difference compared with the levels before and normal group (p<0.05). The CLR at 30 days after stent implanting was significantly correlated with the level of P-selection (r=1.334) and smoking (r=1.053). Conclusion: The levels of CRP, P-selection and sCD40L of in some patient after undergoing coronary stenting increased and may correlated with clopidogrel resistance. The levels of P-selection and smoking were the predictor for clopidogrel resistance.