Surfactant Semiconductors as Trojan Horses in Cell‐Membranes for On‐Demand and Spatial Regulation of Oxidative Stress. Issue 10 (13th January 2023)

• Record Type: Journal Article
• Authors: Jaschke, Marian; Plenge, Masina; Kunkel, Marius; Lehrich, Tina; Schmidt, Julia; Stöckemann, Kilian; Heinemann, Dag; Siroky, Stephan; Ngezahayo, Anaclet; Polarz, Sebastian
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-13
• Subjects: biocompatible amphiphiles -- reactive oxygen species -- self‐assembly -- semiconductor surfactants; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202290
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Oxidative stress is a cause for numerous diseases and aging processes. Thus, researchers are keen to tune the level of intracellular stress and to learn from that. An unusual approach is presented here. The methodology involves multifunctional surfactants. Although their molecular design is nonbiological—a fullerenol head group attached covalently to pi‐conjugated dyes—the surfactants possess superior biocompatibility. Using an intrinsic fluorescence signal as a probe, it is shown that the amphiphiles become incorporated into the Caco‐2 cells. There, they are able to exhibit additional functions. The compound reduces cellular stress in dark reaction pathways. The antagonistic property is activated under irradiation, the photocatalytic production of reactive oxygen species (ROS), resulting in cell damage. The feature is activated even by near‐infrared light (NIR‐light) via a two‐photon process. The properties as molecular semiconductors lead to a trojan horse situation and allows the programming of the spatial distribution of cytotoxicity. Abstract : Surfactants with a fullerenol head and dye tails are biocompatible and can be detected and located in cells by fluorescence probe properties. Two functions are opposed, the protection of cells in the dark versus photocatalytic generation of ROS species. The interplay allows the creation of spatially resolved stress patterns.