Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada. Issue 3 (2005)

• Record Type: Journal Article
• Authors: Tsang, Raymond SW; Law, Dennis KS; Tyler, Shaun D; Stephens, Gwen S; Bigham, Mark; Zollinger, Wendell D
• Is Part Of: Canadian journal of infectious diseases & medical microbiology =. Volume 16:Issue 3(2005)
• Page Start: 171
• Page End: 174
• Publication Date: 2005
• Subjects: Communicable diseases -- Periodicals; Infection -- Periodicals; Communicable diseases; Infection; Communicable Diseases; Communicable Disease Control; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; 616.9
• DOI: 10.1155/2005/216369
• Languages: English
• ISSNs: 1712-9532

Abstract

Abstract : Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.