Epileptic Activity Intrinsically Generated in the Human Cerebellum. Issue 2 (5th June 2020)

• Record Type: Journal Article
• Authors: Okada, Yoshio; Khan, Sheraz; Curran, Ashley; Ahtam, Banu; Hämäläinen, Matti S.; Traub, Roger D.; Pearl, Phillip L.
• Is Part Of: Annals of neurology. Volume 88:Issue 2(2020)
• Page Start: 418
• Page End: 422
• Publication Date: 2020-06-05
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.25779
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Analysis of generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor was the dominant interictal spike generator and could initiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generating epileptic activity. ANN NEUROL 2020;88:418–422.