The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis. (15th November 2021)

• Record Type: Journal Article
• Authors: Bergamaschi, Roberto; Ponzano, Marta; Schiavetti, Irene; Carmisciano, Luca; Cordioli, Cinzia; Filippi, Massimo; Radaelli, Marta; Immovilli, Paolo; Capobianco, Marco; De Rossi, Nicola; Brichetto, Giampaolo; Cocco, Eleonora; Scandellari, Cinzia; Cavalla, Paola; Pesci, Ilaria; Zito, Antonio; Confalonieri, Paolo; Marfia, Girolama Alessandra; Perini, Paola; Inglese, Matilde; Trojano, Maria; Brescia Morra, Vincenzo; Pisoni, Enrico; Tedeschi, Gioacchino; Comi, Giancarlo; Battaglia, Mario Alberto; Patti, Francesco; Salvetti, Marco; Sormani, Maria Pia
• Other Names: Abbadessa Gianmarco investigator.; Aguglia Umberto investigator.; Allegorico Lia investigator.; Allegri Rossi Beatrice Maria investigator.; Alteno Anastasia investigator.; Amato Maria Pia investigator.; Annovazzi Pietro investigator.; Antozzi Carlo investigator.; Appendino Lucia investigator.; Arena Sebastiano investigator.; Baione Viola investigator.; Balgera Roberto investigator.; Barcella Valeria investigator.; Baroncini Damiano investigator.; Barrilà Caterina investigator.; Battaglia Mario A. investigator.; Bellacosa Alessandra investigator.; Bellucci Gianmarco investigator.; Bergamaschi Roberto investigator.; Bergamaschi Valeria investigator.; Bezzini Daiana investigator.; Biolzi Beatrice investigator.; Bisecco Alvino investigator.; Bonavita Simona investigator.; Borriello Giovanna investigator.; Bosa Chiara investigator.; Bosco Antonio investigator.; Bovis Francesca investigator.; Bozzali Marco investigator.; Brambilla Laura investigator.; Brescia Morra Vincenzo investigator.; Brichetto Giampaolo investigator.; Buccafusca Maria investigator.; Bucciantini Elisabetta investigator.; Bucello Sebastiano investigator.; Buscarinu Maria Chiara investigator.; Cabboi Maria Paola investigator.; Calabrese Massimiliano investigator.; Calabria Francesca investigator.; Caleri Francesca investigator.; Camilli Federico investigator.; Caniatti Luisa Maria investigator.; Cantello Roberto investigator.; Capobianco Marco investigator.; Capra Ruggero investigator.; Capuano Rocco investigator.; Carmisciano Luca investigator.; Carta Patrizia investigator.; Cavalla Paola investigator.; Celani Maria Grazia investigator.; Cellerino Maria investigator.; Cerqua Raffaella investigator.; Chisari Clara investigator.; Clerici Raffaella investigator.; Clerico Marinella investigator.; Cocco Eleonora investigator.; Cola Gaia investigator.; Comi Giancarlo investigator.; Confalonieri Paolo investigator.; Conte Antonella investigator.; Conti Marta Zaffira investigator.; Cordano Christian investigator.; Cordera Susanna investigator.; Cordioli Cinzia investigator.; Corea Francesco investigator.; Correale Claudio investigator.; Cottone Salvatore investigator.; Crescenzo Francesco investigator.; Curti Erica investigator.; d'Ambrosio Alessandro investigator.; D'Amico Emanuele investigator.; Danni Maura Chiara investigator.; d'Arma Alessia investigator.; Dattola Vincenzo investigator.; de Biase Stefano investigator.; De Luca Giovanna investigator.; De Mercanti Stefania Federica investigator.; De Mitri Paolo investigator.; De Rossi Nicola investigator.; De Stefano Nicola investigator.; Della Cava Marco investigator.; di Napoli Mario investigator.; Di Sapio Alessia investigator.; Docimo Renato investigator.; Dutto Anna investigator.; Evangelista Luana investigator.; Fanara Salvatore investigator.; Ferraro Diana investigator.; Ferrò Maria Teresa investigator.; Filippi Massimo investigator.; Fioretti Cristina investigator.; Fratta Mario investigator.; Frau Jessica investigator.; Fronza Marzia investigator.; Furlan Roberto investigator.; Gajofatto Alberto investigator.; Gallo Antonio investigator.; Gallo Paolo investigator.; Gasperini Claudio investigator.; Ghazaryan Anna investigator.; Giometto Bruno investigator.; Gobbin Francesca investigator.; Govone Flora investigator.; Granella Franco investigator.; Grange Erica investigator.; Grasso Maria Grazia investigator.; Guareschi Angelica investigator.; Guaschino Clara investigator.; Guerrieri Simone investigator.; Guidetti Donata investigator.; Iaffaldano Pietro investigator.; Ianniello Antonio investigator.; Iasevoli Luigi investigator.; Immovilli Paolo investigator.; Imperiale Daniele investigator.; Infante Maria Teresa investigator.; Inglese Matilde investigator.; Iodice Rosa investigator.; Iovino Aniello investigator.; Konrad Giovanna investigator.; Landi Doriana investigator.; Lanzillo Roberta investigator.; Lapucci Caterina investigator.; Lavorgna Luigi investigator.; L'Episcopo Maria Rita investigator.; Leva Serena investigator.; Liberatore Giuseppe investigator.; Lo Re Marianna investigator.; Longoni Marco investigator.; Lopiano Leonardo investigator.; Lorefice Lorena investigator.; Lucchini Matteo investigator.; Lus Giacomo investigator.; Maimone Davide investigator.; Malentacchi Maria investigator.; Mallucci Giulia investigator.; Malucchi Simona investigator.; Mancinelli Chiara Rosa investigator.; Mancinelli Luca investigator.; Manganotti Paolo investigator.; Maniscalco Giorgia Teresa investigator.; Mantero Vittorio investigator.; Marangoni Sabrina investigator.; Marastoni Damiano investigator.; Marfia Girolama Alessandra investigator.; Marinelli Fabiana investigator.; Marti Alessandro investigator.; Martinelli Boneschi Filippo investigator.; Masserano Zoli Federco investigator.; Matta Francesca investigator.; Mendozzi Laura investigator.; Meucci Giuseppe investigator.; Miante Silvia investigator.; Miele Giuseppina investigator.; Milano Eva investigator.; Mirabella Massimiliano investigator.; Missione Rosanna investigator.; Moccia Marcello investigator.; Moiola Lucia investigator.; Montepietra Sara investigator.; MontiBragadin Margherita investigator.; Montini Federico investigator.; Motta Roberta investigator.; Nardone Raffaele investigator.; Nicoletti Carolina Gabri investigator.; Nobile‐Orazio Eduardo investigator.; Nozzolillo Agostino investigator.; Onofrj Marco investigator.; Orlandi Riccardo investigator.; Palmieri Anna investigator.; Paolicelli Damiano investigator.; Pasquali Livia investigator.; Pastò Luisa investigator.; Patti Francesco investigator.; Pedrazzoli Elisabetta investigator.; Perini Paola investigator.; Pesci Ilaria investigator.; Petracca Maria investigator.; Petrone Alfredo investigator.; Piantadosi Carlo investigator.; Pietroboni Anna M. investigator.; Pinardi Federica investigator.; Ponzano Marta investigator.; Portaccio Emilio investigator.; Pozzato Mattia investigator.; Pozzilli Carlo investigator.; Prosperini Luca investigator.; Protti Alessandra investigator.; Radaelli Marta investigator.; Ragonese Paolo investigator.; Rasia Sarah investigator.; Realmuto Sabrina investigator.; Repice Anna investigator.; Rigoni Eleonora investigator.; Rilla Maria Teresa investigator.; Rinaldi Francesca investigator.; Romano Calogero Marcello investigator.; Ronzoni Marco investigator.; Rovaris Marco investigator.; Ruscica Francesca investigator.; Sabattini Loredana investigator.; Salemi Giuseppe investigator.; Salvetti Marco investigator.; Saraceno Lorenzo investigator.; Sartori Alessia investigator.; Sartori Arianna investigator.; Sbragia Elvira investigator.; Scandellari Cinzia investigator.; Scarano Giuditta Ilaria investigator.; Scarano Valentina investigator.; Schiavetti Irene investigator.; Sessa Maria investigator.; Sgarito Caterina investigator.; Sibilia Grazia investigator.; Siciliano Gabriele investigator.; Signori Alessio investigator.; Signoriello Elisabetta investigator.; Sinisi Leonardo investigator.; Sireci Francesca investigator.; Sola Patrizia investigator.; Solaro Claudio investigator.; Sormani Maria Pia investigator.; Sotgiu Stefano investigator.; Sparaco Maddalena investigator.; Stromillo Maria Laura investigator.; Strumia Silvia investigator.; Susani Emanuela Laura investigator.; Tabiadon Giulietta investigator.; Teatini Francesco investigator.; Tedeschi Gioacchino investigator.; Tomassini Valentina investigator.; Tonietti Simone investigator.; Torri Clerici Valentina investigator.; Tortorella Carla investigator.; Toscano Simona investigator.; Totaro Rocco investigator.; Trojano Maria investigator.; Trotta Maria investigator.; Turano Gabriella investigator.; Ulivelli Monica investigator.; Valentino Manzo investigator.; Vaula Giovanna investigator.; Vecchio Domizia investigator.; Vercellino Marco investigator.; Verrengia Elena Pinuccia investigator.; Vianello Marika investigator.; Virgilio Eleonora investigator.; Vitetta Francesca investigator.; Vollaro Stefano investigator.; Zaffaroni Mauro investigator.; Zampolini Mauro investigator.; Zarbo Ignazio Roberto investigator.; Zito Antonio investigator.; Zuliani Luigi investigator.;
• Is Part Of: European journal of neurology. Volume 29:Number 2(2022)
• Page Start: 535
• Page End: 542
• Publication Date: 2021-11-15
• Subjects: air pollution -- coronavirus -- multiple sclerosis; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.15167
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract: Background and purpose: Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m 3 (PM2.5), may contribute to severe COVID‐19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID‐19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID‐19 severity amongst PwMS. Methods: Data were retrieved from an Italian web‐based platform (MuSC‐19) which includes PwMS with COVID‐19. PM2.5 2016–2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID‐19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID‐19 severity. Results: In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID‐19 course (odds ratio 1.90; p = 0.009). Conclusions: Even if several other factors explain the unfavourable course of COVID‐19 in PwMS, the role of air pollutants must be considered and further investigated. Abstract : Air pollution, often assessed by particulate matter with diameter below 2.5 µg/m 3, may contribute to severe COVID‐19 courses. 1087 patients were included, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died. Even if several other factors explain the unfavourable course of COVID‐19 in patients with multiple sclerosis, the role of air pollutants must be considered and further investigated.