Pharmacogenomics in Cardiovascular Diseases. Issue 7 (7th July 2021)

• Record Type: Journal Article
• Authors: McDonough, Caitrin W.
• Is Part Of: Current protocols. Volume 1:Issue 7(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-07
• Subjects: antiplatelet therapy -- antihypertensive therapy -- cardiovascular -- complex diseases -- pharmacogenomics; Life sciences -- Laboratory manuals -- Periodicals; Biology -- Laboratory manuals -- Periodicals; Life sciences -- Technique -- Periodicals; Biology -- Technique -- Periodicals; 570.028
• DOI: 10.1002/cpz1.189
• Languages: English
• ISSNs: 2691-1299

Abstract

Abstract: Cardiovascular pharmacogenomics is the study and identification of genomic markers that are associated with variability in cardiovascular drug response, cardiovascular drug−related outcomes, or cardiovascular drug−related adverse events. This overview presents an introduction and historical background to cardiovascular pharmacogenomics, and a protocol for designing a cardiovascular pharmacogenomics study. Important considerations are also included for constructing a cardiovascular pharmacogenomics phenotype, designing the replication or validation strategy, common statistical approaches, and how to put the results in context with the cardiovascular drug or cardiovascular disease under investigation. © 2021 Wiley Periodicals LLC. Basic Protocol : Designing a cardiovascular pharmacogenomics study