Role of co- and post-translational modifications of SFKs in their kinase activation. (2nd January 2020)

• Record Type: Journal Article
• Authors: Cai, Mei-Lian; Wang, Meng-Yan; Zhang, Cong-Hui; Wang, Jun-Xia; Liu, Hong; He, Hong-Wei; Zhao, Wu-Li; Xia, Gui-Ming; Shao, Rong-Guang
• Is Part Of: Journal of drug targeting. Volume 28:Number 1(2020)
• Page Start: 23
• Page End: 32
• Publication Date: 2020-01-02
• Subjects: Src family kinases (SFKs) -- co- and post-translational modifications -- domain -- activation -- kinase activity; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.1080/1061186X.2019.1616297
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: Src family kinases (SFKs) are non-receptor tyrosine kinases and are involved in various cellular functions (proliferation, differentiation, migration, survival and invasion) by regulating downstream pathways. Considerable evidence suggests that co- and post-translational modifications are highly related to the activation of SFKs and their downstream signals. How SFKs are activated and how their subsequent cascades were regulated has been reviewed in previous reports. However, the contribution of co- and post-translational modification to SFKs activation has not been fully elucidated. This review focuses on the effect of these modifications on SFKs activity according to structural and biochemical studies and uncovers the significance of co-and post-translational modifications in the regulation of SFKs activity.