Declining Effectiveness of Herpes Zoster Vaccine in Adults Aged ≥60 Years. (9th February 2016)

• Record Type: Journal Article
• Authors: Tseng, Hung Fu; Harpaz, Rafael; Luo, Yi; Hales, Craig M.; Sy, Lina S.; Tartof, Sara Y.; Bialek, Stephanie; Hechter, Rulin C.; Jacobsen, Steven J.
• Is Part Of: Journal of infectious diseases. Volume 213:Number 12(2016:Jun. 15)
• Page Start: 1872
• Page End: 1875
• Publication Date: 2016-02-09
• Subjects: herpes zoster -- adult vaccination -- shingles -- varicella zoster virus; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiw047
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Understanding long-term effectiveness of herpes zoster (HZ) vaccine is critical for determining vaccine policy. 176 078 members of Kaiser Permanente ≥60 years vaccinated with HZ vaccine and three matched unvaccinated members were included. Hazard ratios and 95% confidence intervals (CIs) associated with vaccination at each year following vaccination were estimated by Cox regression model. The effectiveness of HZ vaccine decreased from 68.7% (95% CI, 66.3%–70.9%) in the first year to 4.2% (95% CI, −24.0% to 25.9%) in the eighth year. This rapid decline in effectiveness of HZ vaccine suggests that a revaccination strategy may be needed, if feasible.