Functional Restoration of Elbow Flexion in Nonobstetric Brachial Plexus Injuries: A Meta-Analysis of Nerve Transfers Versus Grafts. (1st September 2019)

• Record Type: Journal Article
• Authors: Texakalidis, Pavlos; Hardcastle, Nathan; Tora, Muhibullah S; Boulis, Nicholas M
• Is Part Of: Neurosurgery. Volume 66(2010)Supplement 1
• Publication Date: 2019-09-01
• Subjects: Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyz310_140
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: INTRODUCTION: Restoration of elbow flexion is the priority in traumatic brachial plexus injuries. Surgical approaches commonly include nerve transfers and nerve grafting. Our objective was to evaluate the safety and efficacy profile of nerve transfers vs grafting for traumatic nonobstetric brachial plexus injuries. METHODS: This systematic literature review was performed according to the PRISMA guidelines. Eligible studies were identified through a search of PubMed until November 2018. A random-effects model meta-analysis was conducted, and the I-square was used to assess heterogeneity. The Medical Research Scale (MRC) score was used to assess the efficacy of the procedures. RESULTS: A total of 9 studies comprising 490 patients overall were identified. In the pooled analysis, functional recovery of elbow flexion defined as MRC = M3, was superior in the transfer ( N = 272/350, 77.7%) compared to the graft group ( N = 99/140, 70.7%); however statistical significance was not reached (OR: 1.95; 95% CI: 0.79-4.83; I2: 58.8%). However, the odds for successful restoration of elbow flexion (MRC = M3) were significantly higher when the ulnar (OR: 12.20; 95% CI: 3.05-48.80; I2: 0%) or pectoral nerves (OR: 9.69; 95% CI: 1.83-51.25; I2: 0%) were used as healthy donors for the transfer compared to the graft procedures. Results between the 2 groups were similar when the intercostal, spinal accessory, thoracodorsal, contralateral C7 and phrenic nerves were used as donors for the transfer procedures. CONCLUSION: The ulnar or pectoral nerve to musculocutaneous is associated with statistically significant superior rates of elbow flexion recovery. No differences were identified in the pooled analysis or the subgroups of other donors used in nerve transfers. Future randomized studies or prospective cohorts are needed to validate our results.