Neurologic Deterioration in Patients With Moyamoya Disease During Pregnancy, Delivery, and Puerperium. (1st September 2019)

• Record Type: Journal Article
• Authors: Park, Wonhyoung; Kim, Minwoo; Ahn, Jae Sung
• Is Part Of: Neurosurgery. Volume 66(2010)Supplement 1
• Publication Date: 2019-09-01
• Subjects: Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyz310_500
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: INTRODUCTION: We reviewed our clinical experience of patients with moyamoya disease (MMD) who gave birth and assessed characteristics of those experiencing neurologic deterioration. METHODS: The patients were classified into patients diagnosed with MMD during pregnancy and puerperium (group 1) and those diagnosed before pregnancy (group 2). We retrospectively reviewed patient characteristics, MMD treatment, neurologic symptoms before and during pregnancy and/after puerperium, obstetrical history, and delivery type in groups 1 and 2. RESULTS: Group 1 included 2 patients with a deterioration of preexisting transient ischemic attacks (TIAs) and acute cerebral infarction and 1 patient with seizures and newly developed TIAs during pregnancy and/or puerperium. Group 2 included 20 patients with 23 pregnancies. In group 2, 4 patients had deterioration of TIAs during pregnancy and puerperium. There were significant differences between the cases without neurologic deterioration and with deterioration in group 2 (TIAs ! 10 before pregnancy, 0% vs 75%, P = .002; severely reduced regional cerebrovascular reserve on single-photon emission computed tomography, 10.5% vs 100%, P = .002; and surgical revascularization before pregnancy, 75% vs 15.8%, P = .04). In groups 1 and 2, 6 of the 7 cases in which TIAs occurred or worsened during pregnancy or puerperium recovered to prepregnancy TIA levels after puerperium. CONCLUSION: Patients with severely reduced regional cerebrovascular reserve on single-photon emission computed tomography and frequent TIAs before pregnancy may experience neurologic deterioration during pregnancy, delivery, and puerperium. Surgical revascularization before pregnancy may decrease neurologic deterioration during these periods.