Microneedles for transdermal diagnostics: Recent advances and new horizons. (February 2020)

• Record Type: Journal Article
• Authors: Liu, Gui-Shi; Kong, Yifei; Wang, Yensheng; Luo, Yunhan; Fan, Xudong; Xie, Xi; Yang, Bo-Ru; Wu, Mei X.
• Is Part Of: Biomaterials. Volume 232(2020)
• Publication Date: 2020-02
• Subjects: Microneedle -- Point-of-care -- Minimally invasive -- Wearable or portable biosensors -- Home-based diagnosis -- Continuous monitoring; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2019.119740
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Point-of-care testing (POCT), defined as the test performed at or near a patient, has been evolving into a complement to conventional laboratory diagnosis by continually providing portable, cost-effective, and easy-to-use measurement tools. Among them, microneedle-based POCT devices have gained increasing attention from researchers due to the glorious potential for detecting various analytes in a minimally invasive manner. More recently, a novel synergism between microneedle and wearable technologies is expanding their detection capabilities. Herein, we provide an overview on the progress in microneedle-based transdermal biosensors. It covers all the main aspects of the field, including design philosophy, material selection, and working mechanisms as well as the utility of the devices. We also discuss lessons from the past, challenges of the present, and visions for the future on translation of these state-of-the-art technologies from the bench to the bedside.