Molecular mechanisms of reprogramming of differentiated cells into stem cells in the moss Physcomitrium patens. (February 2022)

• Record Type: Journal Article
• Authors: Ishikawa, Masaki; Hasebe, Mitsuyasu
• Is Part Of: Current opinion in plant biology. Volume 65(2022)
• Publication Date: 2022-02
• Subjects: Reprogramming -- Stem cell -- Physcomitrium patens -- Wounding -- DNA damage; Plant molecular biology -- Periodicals; 571.205
• DOI: 10.1016/j.pbi.2021.102123
• Languages: English
• ISSNs: 1369-5266

Abstract

Abstract: Plant and animal stem cells can self-renew and give rise to differentiated cells to form tissues or organs. Unlike differentiated cells in animals, those in land plants can be readily reprogrammed into stem cells, reflecting the plasticity of plant cell identity. The moss Physcomitrium patens (synonym: Physcomitrella patens ) is highly regenerable, and its leaf cells can be reprogrammed into stem cells in response to wounding or by transient DNA damage without wounding. Wounding and DNA damage induce STEM CELL-INDUCING FACTOR 1, an APETALA2/ETHYLENE RESPONSE FACTOR. Here, we summarize the genetic networks that regulate cellular reprogramming in P. patens and the roles of STEMIN1 and discuss the generality and divergence of the molecular mechanisms underlying cellular reprogramming in land plants and animals. Graphical abstract: Image 1 Highlights: Some types of cells including terminally differentiated cells in land plants can be reprogrammed into stem cells by wounding. Wounding and DNA damage change Physcomitrium (synonym: Physcomitrella ) patens leaf cells into chloronema apical stem cells. S TEMIN, PpWOX13L, PpCSP and ATG genes form a regulatory network of wound-induced reprogramming in P . patens. CSPs with putative RNA-binding activity are involved in reprogramming into stem cells in both mammals and land plants. Stem cell formation by wounding and DNA damage should be adaptive for land plants to survive under a harsh environment.