Advances in polysaccharide nanocrystals as pharmaceutical excipients. (15th June 2021)

• Record Type: Journal Article
• Authors: Si, Yanxue; Luo, Huize; Zhou, Fengshan; Bai, Xinyi; Han, Lu; Sun, Huimin; Cha, Ruitao
• Is Part Of: Carbohydrate polymers. Volume 262(2021)
• Publication Date: 2021-06-15
• Subjects: Ag NPs silver nanoparticles -- ALG alginate -- A-MCNCs amino acid (l-leucine) linked cellulose nanocrystals modified by maleic anhydride -- APIs active pharmaceutical ingredients -- ASNs acetylated starch nanocrystals -- BSA bovine serum albumin -- CCNCs carboxylated cellulose nanocrystals -- CD cyclodextrin -- C/DACs collagen/dialdehyde cellulose nanocrystals -- ChNCs chitin nanocrystals -- CNCs cellulose nanocrystals -- CS chitosan -- DOX doxorubicin -- ECNCs esterified cellulose nanocrystals -- 5-FU 5-fluorouracil -- MTX methotrexate -- MxG-CCNCs carboxylated cellulose nanocrystals derived from Miscanthus x. Giganteus -- OSA octenyl succinic anhydride -- PEC polyelectrolyte complexes -- PEG polyethylene glycol -- PLA poly-lactic acid -- PLLA poly(l, l-lactide) -- PM poloxamer copolymer -- PMMA poly(methyl methacrylate) -- PNIPAM poly(N-isopropylacrylamide) -- PNs polysaccharide nanocrystals -- PTX paclitaxel -- PVA poly(vinyl alcohol) -- SNCs starch nanocrystals -- TC tetracycline -- TFLX tosufloxacintosilate -- XG xanthan gum; Polysaccharide nanocrystals -- Cellulose nanocrystals -- Starch nanocrystals -- Chitin nanocrystals -- Pharmaceutical excipients; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.117922
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: We summarize the pharmaceutical applications of polysaccharide nanocrystals (PNs). We discuss regulatory issues of PNs as pharmaceutical excipients. We raise challenges and potentials of PNs in pharmaceutical field. Abstract: Polysaccharide nanocrystals (PNs) are attractive pharmaceutical excipients due to their abundant surface hydroxyl groups, high surface charges, prominent mechanical properties, excellent fluidity, and good swelling properties. In this review, we summarize three kinds of PNs, including cellulose nanocrystals (CNCs), starch nanocrystals (SNCs), and chitin nanocrystals (ChNCs). We introduce the applications of PNs as stabilizers, adsorbents, film-forming materials, gel materials, disintegrants, and ointment matrices. We focus on the advantages of PNs to improve mechanical properties, thermal stability, therapeutic effect, biocompatibility, and release of active pharmaceutical ingredients. We discuss regulatory issues of PNs. We finally propose the challenges and future perspectives of PNs as pharmaceutical excipients.