SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10. Issue 12 (20th October 2021)

• Record Type: Journal Article
• Authors: Gomes, André M. C.; Farias, Guilherme B.; Dias‐Silva, Manuel; Laia, Joel; Trombetta, Amelia C.; Godinho‐Santos, Ana; Rosmaninho, Pedro; Santos, Diana F.; Conceição, Carolina M.; Costa‐Reis, Renato; Adão‐Serrano, Maria; Mota, Catarina; Almeida, Afonso R. M.; Sousa, Ana E.; Fernandes, Susana M.
• Is Part Of: European journal of immunology. Volume 51:Issue 12(2021)
• Page Start: 3194
• Page End: 3201
• Publication Date: 2021-10-20
• Subjects: COVID‐19 -- SARS‐CoV2 -- Lung recovery -- Innate lymphoid cells -- CCR10; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202149311
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract: Accelerate lung repair in SARS‐CoV‐2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS‐CoV‐2 infection. COVID‐19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10 + ILC2 emerge as relevant contributors to SARS‐CoV‐2 pneumonia recovery. Abstract : Moderate to severe COVID‐19 is associated with an overall decrease in all innate lymphoid cells' subsets in parallel with the well‐known lymphopenia. We report, in association with the oxygenation improvement, a significant expansion of ILC1, irrespectively of CD161 expression, and of CCR10 expressing ILC2, suggesting their involvement in lung regeneration.