Outcomes of donor versus partner sperm in intrauterine insemination in women aged 38 years and older. Issue 3 (19th April 2021)

• Record Type: Journal Article
• Authors: Frank, Russell; Steiner, Naama; Al Shatti, Maryam; Ruiter‐Ligeti, Jacob; Dahan, Michael H.
• Is Part Of: International journal of gynaecology and obstetrics. Volume 156:Issue 3(2022)
• Page Start: 516
• Page End: 520
• Publication Date: 2021-04-19
• Subjects: advanced maternal age -- donor sperm -- infertility -- intrauterine insemination -- partner sperm -- pregnancy; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.13694
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To compare pregnancy rates of donor versus partner sperm in intrauterine insemination (IUI) cycles in women aged 38 years and above. Methods: A retrospective cohort study was performed using data from 944 women aged 38–43 years old who underwent a combined 1596 IUI cycles at an academic fertility clinic in Montreal, Canada between February 2009 to April 2018. Results: Partner sperm was used in 1421 cycles (89.0%), and donor sperm was inseminated in 175 cycles (11.0%). Mean ages of the women were 39.8 (±1.5) and 40.2 (±1.6) years in the partner and donor insemination groups, respectively ( P < 0.001). Positive serum (β human chorionic gonadotropin) pregnancy rate in the partner sperm group was 9.0% ( n = 128) whereas that in the donor insemination group was 9.7% ( n = 17) ( P = 0.759). Clinical pregnancy rates were 5.8% ( n = 83) and 8.0% ( n = 14) in the respective groups ( P = 0.260). There were five multiple gestation (twin) pregnancies in the cohort, three in those undergoing IUI with partner sperm and two in those undergoing IUI with donor sperm. Conclusion: In women aged 38–43 years undergoing IUI with controlled ovarian stimulation, using donor sperm, compared with partner sperm, did not increase rate of pregnancy. Abstract : Donor sperm, when compared with partner sperm, does not increase pregnancy rates from intrauterine insemination in women with advanced reproductive ages 38–42 years old.