O-72 Kidney cancer and exposure to mitotoxic fungicides (SDHIs and strobilurins) in the AGRIculture and CANcer cohort (AGRICAN). (14th March 2023) - Nassar, Carine
Abstract : Introduction: Succinate dehydrogenase inhibitors (SDHIs) and strobilurins are two groups of fungicides introduced in the 1990s and 2000s to the agricultural market, including overall around 24 molecules. A deficiency in the subunit of a SDHI-blocked enzyme has been observed in cases of K idney Cancer (KC). We aimed at assessing the incidence of KC in individuals exposed to these fungicides within the AGRICAN cohort (N=181 842 participants). Material and Methods: Incident KCs were identified from enrolment (2005-2007) to December 2017. Pesticide exposures of interest were identified by cross-referencing the PESTIMAT tables with the AGRICAN enrollment questionnaire (exact years of start and end of pesticide use (in the field or on seeds) on 10 different crops). Cox models with age as a time scale were used. Results: Five SDHIs and 3 strobilurins had been used, on crops (vineyard, potato, fruit, corn, peas and wheat/barley), for at least 5 years prior to enrolment, with respectively 114 and 89 exposed KC in males. Analyzing the specific use of SDHIs and strobilurins on crops, we reported positive associations: (i) for SDHIs: Fenfuram (HR 1.50 (1.04-2.16)), Oxycarboxin (HR 1.49 (1.10-2.00)) and Carboxin (HR 1.44 (1.06-1.96)). (ii) for strobilurins: Famoxadone (HR 3.5 (2.4-5.06)), Azoxystrobin (HR 3.20 (2.30-4.50)) and Kresoxim-Methyl (HR 2.6 (1.89-3.48)). Duration effect was positive for Fenfuram and Mepronil and all 3 strobilurins. Conclusion: We observed positive associations between KCs and some SDHIs and strobilurin use in male farmers. We had too few females directly exposed to these fungicides. Next steps should include a cluster analysis and score considering the frequency, intensity and probability of using the pesticides under study.