Ifosfamide-induced neurotoxicity reversal with continuous veno-venous hemodialysis. A case report. (September 2013)

• Record Type: Journal Article
• Authors: Cherry, Mohamad A; Bhardwaj, Himanshu; Hopps, Sarah; Srour, Samer; Pant, Shubham
• Is Part Of: Journal of oncology pharmacy practice. Volume 19:Number 3(2013)
• Page Start: 261
• Page End: 264
• Publication Date: 2013-09
• Subjects: Ifosfamide neurotoxicity and nephrotoxicity -- chemotherapy side effects -- hemodialysis; Cancer -- Chemotherapy -- Periodicals; Clinical pharmacology -- Periodicals; 616.994061
• DOI: 10.1177/1078155212459285
• Languages: English
• ISSNs: 1078-1552

Abstract

Ifosfamide is an alkylating agent used to treat different types of malignancies including lymphomas, sarcomas and germinal cell tumors. Symptoms of ifosfamide neurotoxicity can range from mild confusion, dizziness and hallucination to overt encephalopathy. Various treatment options like methylene blue, albumin infusion and rarely hemodialysis have been used to treat ifosfamide neurotoxicity. We hereby report a case of a patient with relapsed diffuse large B cell lymphoma who received methylene blue after experiencing acute renal failure and encephalopathy due to ifosfamide with no improvement. The prompt use of hemodialysis in this case has led to reversal of both renal failure and neurotoxicity.