Model-Independent Evaluation of Tumor Markers and a Logistic-Tree Approach to Diagnostic Decision Support. Issue 4 (16th December 2014)

• Record Type: Journal Article
• Authors: Ni, Weizeng; Huang, Samuel H.; Su, Qiang; Shi, Jinghua
• Is Part Of: Journal of healthcare engineering. Volume 5:Issue 4(2014)
• Page Start: 393
• Page End: 410
• Publication Date: 2014-12-16
• Subjects: cancer diagnosis -- decision support -- machine learning -- tumor marker; Hospital buildings -- Environmental engineering -- Periodicals; Medical technology -- Periodicals; Medical informatics -- Periodicals; 610.28
• DOI: 10.1260/2040-2295.5.4.393
• Languages: English
• ISSNs: 2040-2295

Abstract

Abstract : Sensitivity and specificity of using individual tumor markers hardly meet the clinical requirement. This challenge gave rise to many efforts, e.g., combing multiple tumor markers and employing machine learning algorithms. However, results from different studies are often inconsistent, which are partially attributed to the use of different evaluation criteria. Also, the wide use of model-dependent validation leads to high possibility of data overfitting when complex models are used for diagnosis. We propose two model-independent criteria, namely, area under the curve (AUC) and Relief to evaluate the diagnostic values of individual and multiple tumor markers, respectively. For diagnostic decision support, we propose the use of logistic-tree which combines decision tree and logistic regression. Application on a colorectal cancer dataset shows that the proposed evaluation criteria produce results that are consistent with current knowledge. Furthermore, the simple and highly interpretable logistic-tree has diagnostic performance that is competitive with other complex models.