Elevated IL-1α and CXCL10 Serum Levels Occur in Patients with Homozygous Sickle Cell Disease and a History of Acute Splenic Sequestration. Issue 5 (21st May 2013)

• Record Type: Journal Article
• Authors: Driss, Adel; Wilson, Nana O.; Mason, Karlene; Hyacinth, Hyacinth I.; Hibbert, Jacqueline M.; Serjeant, Graham R.; Stiles, Jonathan K.
• Is Part Of: Disease markers. Volume 32:Issue 5(2012)
• Page Start: 295
• Page End: 300
• Publication Date: 2013-05-21
• Subjects: Sickle cell anemia -- biomarkers -- splenectomy -- spleen -- interleukins -- cytokine -- acute splenic sequestration -- chronic hypersplenism; Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.3233/DMA-2011-0888
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Acute splenic sequestration (ASS) and chronic hypersplenism are common features of homozygous sickle cell (SS) disease in the first 5 years of life affecting one-third of subjects in the Jamaican Cohort Study. The risk factors are largely unknown and the current study explores a possible role of genetic factors. We have explored these in subjects who received splenectomy in the management of ASS ( n =8) or chronic hypersplenism ( n =9) along with age, gender, and genotype matched controls using Luminex Technology to assess 42 human cytokines/chemokines, including IL-1α and CXCL10 (IP-10). Levels of IL-1α ( p =0.008) and CXCL10 ( p =0.009) were significantly elevated in patients treated by splenectomy compared with the control group. Levels of IL-1α were significantly higher in those with a history of ASS compared with matched normal controls ( p =0.028) but not in those treated for hypersplenism ( p =0.093). Furthermore, several significant differences were found in the median ratios of some cytokine biomarkers between the splenectomized group and the normal controls. These observations are consistent with acute splenic sequestration having a distinct phenotype which may be helpful in predicting those at risk of this complication and suggest that the mechanism of these differences merit further study.