Shaping the host cell environment with viral noncoding RNAs. (15th September 2023)

• Record Type: Journal Article
• Authors: Gorbea, Carlos; Elhakiem, Abdalla; Cazalla, Demián
• Is Part Of: Seminars in cell & developmental biology. Volume 146(2023)
• Page Start: 20
• Page End: 30
• Publication Date: 2023-09-15
• Subjects: Viral noncoding RNA -- miRNA -- Sm-class RNA -- Gene expression -- Long noncoding RNA; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2022.12.008
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Just like the cells they infect viruses express different classes of noncoding RNAs (ncRNAs). Viral ncRNAs come in all shapes and forms, and they usually associate with cellular proteins that are important for their functions. Viral ncRNAs have diverse functions, but they all contribute to the viral control of the cellular environment. Viruses utilize ncRNAs to regulate viral replication, to decide whether they should remain latent or reactivate, to evade the host immune responses, or to promote cellular transformation. In this review we describe the diverse functions played by different classes of ncRNAs expressed by adenoviruses and herpesviruses, how they contribute to the viral infection, and how their study led to insights into RNA-based mechanisms at play in host cells.