Adrenal insufficiency revealing bilateral adrenal hemorrhage related to JAK2 V617F-positive essential thrombocythemia: about two cases. Issue 3 (20th April 2023)

• Record Type: Journal Article
• Authors: Gensous, Noémie; Jourde, Wendy; Salles, Kévin; James, Chloé; Guy, Alexandre; Duffau, Pierre
• Is Part Of: Blood coagulation and fibrinolysis. Volume 34:Issue 3(2023)
• Page Start: 228
• Page End: 231
• Publication Date: 2023-04-20
• Subjects: adrenal gland diseases -- adrenal insufficiency -- myeloproliferative disorders -- anticoagulants -- venous thrombosis; Blood -- Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; Blood Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 612.115
• DOI: 10.1097/MBC.0000000000001196
• Languages: English
• ISSNs: 0957-5235

Abstract

Abstract : Bilateral adrenal hemorrhage is a rare cause of adrenal insufficiency which has been rarely associated with myeloproliferative neoplasms. Here, we report two cases of bilateral adrenal hemorrhage revealed by abdominal pain, malaise, and fatigue in two octogenarian males previously diagnosed with JAK2 V617F-positive essential thrombocythemia. Both patients were on long-term direct oral anticoagulant treatment for atrial fibrillation. Evolution was favorable under steroid replacement therapy, associated with cytoreduction, aspirin, and switch of direct oral anticoagulants for vitamin K antagonists.