Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. Issue 5962 (12th April 1975)

• Record Type: Journal Article
• Authors: Skinner, C; Gaddie, J; Palmer, K N
• Is Part Of: BMJ. Volume 2:Issue 5962(1975)
• Page Start: 59
• Page End: 61
• Publication Date: 1975-04-12
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.2.5962.59
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics. AH 5158, like propranolol, is a non-cardioselective beta-adrenoceptor-blocking drug, but unlike propranolol it also has an alpha-adrenoceptor-blocking action. Both drugs produced equivalent cardiac(beta1) blockade, but propranolol produced bronchoconstriction, whereas AH 5158 did not. Hence the alpha-blocking action of AH 5158 seems to prevent the bronchoconstrictor effects of propranolol in these patients.