Circulating Pregenomic Hepatitis B Virus RNA Is Primarily Full-length in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogue Therapy. (20th July 2020)

• Record Type: Journal Article
• Authors: Anderson, Mark; Gersch, Jeffery; Luk, Ka-Cheung; Dawson, George; Carey, Ivana; Agarwal, Kosh; Shah, Pir; Dusheiko, Geoffrey; Lau, Daryl; Cloherty, Gavin
• Is Part Of: Clinical infectious diseases. Volume 72:Number 11(2021)
• Page Start: 2029
• Page End: 2031
• Publication Date: 2020-07-20
• Subjects: hepatitis B virus -- pregenomic RNA -- viral diagnostic assay -- quantitative polymerase chain reaction; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1015
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Hepatitis B virus RNA is detectable in the serum of infected patients; however, the RNA species has been questioned. We tested 1827 specimens using a quantitative dual-target quantitative polymerase chain reaction assay and determined that full-length pregenomic RNA is the primary source. These results clarify the major identity of circulating HBV RNA species.