FireProtASR: A Web Server for Fully Automated Ancestral Sequence Reconstruction. Issue 4 (21st December 2020)
- Record Type:
- Journal Article
- Title:
- FireProtASR: A Web Server for Fully Automated Ancestral Sequence Reconstruction. Issue 4 (21st December 2020)
- Main Title:
- FireProtASR: A Web Server for Fully Automated Ancestral Sequence Reconstruction
- Authors:
- Musil, Milos
Khan, Rayyan Tariq
Beier, Andy
Stourac, Jan
Konegger, Hannes
Damborsky, Jiri
Bednar, David - Abstract:
- Abstract: There is a great interest in increasing proteins' stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users' side. FireProt ASR aims to overcome this obstacle by constructing a fully automated workflow, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProt ASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/ .
- Is Part Of:
- Briefings in bioinformatics. Volume 22:Issue 4(2021)
- Journal:
- Briefings in bioinformatics
- Issue:
- Volume 22:Issue 4(2021)
- Issue Display:
- Volume 22, Issue 4 (2021)
- Year:
- 2021
- Volume:
- 22
- Issue:
- 4
- Issue Sort Value:
- 2021-0022-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-12-21
- Subjects:
- ancestral sequence reconstruction -- ancestral enzymes -- evolution -- phylogeny-based analysis -- protein stability
Genetics -- Data processing -- Periodicals
Molecular biology -- Data processing -- Periodicals
Genomes -- Data processing -- Periodicals
572.80285 - Journal URLs:
- http://bib.oxfordjournals.org ↗
http://www.oxfordjournals.org/content?genre=journal&issn=1477-4054 ↗
http://ukcatalogue.oup.com/ ↗
http://firstsearch.oclc.org ↗ - DOI:
- 10.1093/bib/bbaa337 ↗
- Languages:
- English
- ISSNs:
- 1467-5463
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2283.958363
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26956.xml