Water-dispersible unadulterated α-mangostin particles for biomedical applications. Issue 11 (18th November 2020)

• Record Type: Journal Article
• Authors: Bumrung, Jutamad; Chanchao, Chanpen; Intasanta, Varol; Palaga, Tanapat; Wanichwecharungruang, Supason
• Is Part Of: Royal Society open science. Volume 7:Issue 11(2020)
• Publication Date: 2020-11-18
• Subjects: mangosteen extract -- colloid -- self-assembly; Science -- Periodicals; 500
• DOI: 10.1098/rsos.200543
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : α-Mangostin, the extract from pericarp of Garcinia mangostana L . or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its low water solubility, the particle formulations are necessary for the applications of α-mangostin in aqueous media. The particle formulations are usually prepared using surfactants and/or polymers, usually at a larger amount of these auxiliaries than the amount of α-mangostin itself. Here, we show the self-assembly of α-mangostin molecules into water-dispersible particles without a need of any polymers/surfactants. Investigations on chemical structure, crystallinity and thermal properties of the obtained α-mangostin particles, in comparison to the conventional α-mangostin crystalline solid, confirm no formation of the new compound during the particle formation and suggest changes in intermolecular interactions among α-mangostin molecules and significantly more hydroxyl functionality positioned at the particles' surface. The ability of the water suspension of the α-mangostin to inhibit the growth of Propionibacterium acnes, the acne-causing bacteria, is similar to that of the solution of the conventional α-mangostin in 5% dimethyl sulfoxide. Moreover, at 12.7 ppm in an aqueous environment of RAW 264.7 cell culture, α-mangostin suspension exhibits five times higher anti-inflammatory activity than the conventional α-mangostin solution, with the same acceptable cytotoxicity of less than 20% cell death.