New prenylated flavonoid glycosides from the stems of Celastrus orbiculatus with their anti-tumor activities. Issue 9 (3rd May 2023)

• Record Type: Journal Article
• Authors: Xu, Xiangwei; Li, Lijing; Chen, Jun; Lv, Meiyan; Xi, Yiyuan; Lv, Yanxia
• Is Part Of: Natural product research. Volume 37:Issue 9(2023)
• Page Start: 1463
• Page End: 1469
• Publication Date: 2023-05-03
• Subjects: Celastrus orbiculatus -- Celastraceae -- flavonoid glycosides -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.2022671
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new prenylated flavonoid glycosides (1-2 ), together with five known compounds (3-7 ) were isolated from the EtOAc-soluble extract of the stems of Celastrus orbiculatus . The structures of new compounds were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against HepG2, MCF-7, A549, and A2780 cancer cells. Among them, compound 1 showed potential antiproliferative activity on A2780 cells with IC50 value of 10.76 μM. In addition, compound 2 exhibited selective cytotoxic activity on A2780 cells with IC50 value of 26.30 μM. Graphical Abstract: UF0001