Drug Self‐Delivery Systems: Molecule Design, Construction Strategy, and Biological Application. Issue 10 (30th January 2023)

• Record Type: Journal Article
• Authors: Liu, Chengfei; Liu, Caiping; Bai, Yang; Wang, Jingxia; Tian, Wei
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-30
• Subjects: covalent bond -- drug self‐delivery -- supramolecular interaction; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202769
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Drug self‐delivery systems (DSDSs) offer new ways to create novel drug delivery systems (DDSs). In typical DSDSs, therapeutic reagents are not considered passive cargos but active delivery agents of actionable targets. As an advanced drug delivery strategy, DSDSs with positive cooperativity of both free drugs and nanocarriers exhibit the clear merits of unprecedented drug‐loading capacity, minimized systemic toxicity, and flexible preparation of nanoscale deliverables for passive targeted therapy. This review highlights the recent advances and future trends in DSDSs on the basis of two differently constructed structures: covalent and noncovalent bond‐based DSDSs. Specifically, various chemical and architectural designs, fabrication strategies, and responsive and functional features are comprehensively discussed for these two types of DSDSs. In addition, additional comments on the current development status of DSDSs and the potential applications of their molecular designs are presented in the corresponding discussion. Finally, the promising potential of DSDSs in biological applications is revealed and the relationship between preliminary molecular design of DSDSs and therapeutic effects of subsequent DSDSs biological applications is clarified. Abstract : This review highlights the recent advances and future trends in drug self‐delivery systems (DSDSs) on the basis of two differently constructed structures: covalent and noncovalent bond‐based DSDSs. Various chemical and architectural designs, fabrication strategies, and responsive and functional features are comprehensively discussed for these two types of DSDSs.