Secondary erythrocytosis. Issue 4 (3rd April 2023)

• Record Type: Journal Article
• Authors: Babakhanlou, Rodrick; Verstovsek, Srdan; Pemmaraju, Naveen; Rojas-Hernandez, Cristhiam M.
• Is Part Of: Expert review of hematology. Volume 16:Issue 4(2023)
• Page Start: 245
• Page End: 251
• Publication Date: 2023-04-03
• Subjects: Secondary erythrocytosis -- secondary polycythemia -- erythropoietin -- congenital erythrocytosis -- acquired erythrocytosis; Hematology -- Periodicals; 616.15005
• DOI: 10.1080/17474086.2023.2192475
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: Introduction: Erythrocytosis is associated with an elevation of the hemoglobin level above 16.5 g/dL in men and above 16 g/dL in women and an elevation of the hematocrit level above 49% in men and > 48% in women. In primary erythrocytosis, the defect is a clonal disorder in the myeloid compartment of the bone marrow, leading to an increased red cell production. Secondary erythrocytosis is the result of external stimuli to the bone marrow, leading to the production of red cells in excess. Secondary erythrocytosis is more common than primary erythrocytosis and has a broad differential diagnosis. Areas covered: This review will discuss secondary erythrocytosis, its causes, clinical presentation, and both diagnostic and therapeutic approaches. Expert opinion: Although secondary erythrocytosis is more common than PV, there are still challenges and difficulties associated with the distinction between these two conditions. Moreover, there is a paucity of data and guidance when it comes to the management of certain congenital and acquired conditions. A pragmatic approach is recommended in order to identify the cause for this condition. Treatment should be directed at the management of the underlying cause.