Outcomes after lung transplantation in recipients aged 70 years or older. Issue 1 (26th October 2021)

• Record Type: Journal Article
• Authors: Olson, Michael T.; Elnahas, Shaimaa; Biswas Roy, Sreeja; Razia, Deepika; Kang, Paul; Bremner, Ross M.; Smith, Michael A.; Arjuna, Ashwini; Walia, Rajat
• Is Part Of: Clinical transplantation. Volume 36:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-10-26
• Subjects: age -- elderly -- lung transplantation; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14505
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: The proportion of lung transplant (LTx) recipients older than 70 years is increasing, thus we assessed long‐term survival after LTx in this cohort relative to younger counterparts. Patients and methods: We retrospectively reviewed charts of patients who underwent LTx between 2012 and 2016 at our center and divided patients by age: group A (<65 years), B (65–69 years), and C (≥70 years). Survival statistics were evaluated using the Kaplan‐Meier method and Cox regression. Results: The study included 375 LTx recipients: 221 (58.9%) in group A, 109 (29.1%) in group B, and 45 (12.0%) in group C. Group C was mostly men (37/45 [82.2%]; P = 0.003) and had the highest mean serum creatinine at listing ( P = 0.02). Survival at 1, 3, and 5 years after transplant in group A (93.2%, 70.1%, 58.8%) was significantly higher than group B (83.5%, 59.6%, 44.0%; P = 0.005, 0.028, 0.006, log‐rank test) and was similar to group C (86.7%, 64.4%, 57.8%), although trended higher at 1 year ( P = 0.139, 0.274, 0.489, log‐rank test). Groups B and C had comparable survival at all time points. Conclusions: Although survival decreased after age 65, long‐term survival was comparable between LTx recipients aged 65–69 years and recipients ≥70 years.