The Accuracy of Incident Vertebral Fracture Detection in Children Using Targeted Case‐Finding Approaches. (20th April 2021)

• Record Type: Journal Article
• Authors: Ma, Jinhui; Siminoski, Kerry; Wang, Peiyao; Jaremko, Jacob L; Koujok, Khaldoun; Matzinger, Mary Ann; Shenouda, Nazih; Lentle, Brian; Alos, Nathalie; Cummings, Elizabeth A; Ho, Josephine; Houghton, Kristin; Miettunen, Paivi M; Scuccimarri, Rosie; Rauch, Frank; Ward, Leanne M
• Is Part Of: Journal of bone and mineral research. Volume 36:Number 7(2021)
• Page Start: 1255
• Page End: 1268
• Publication Date: 2021-04-20
• Subjects: DISEASES AND DISORDERS OF/RELATED TO BONE -- OSTEOPOROSIS -- PRACTICE/POLICY‐RELATED ISSUES -- FRACTURE RISK ASSESSMENT -- ANALYSIS/QUANTITATION OF BONE -- DXA; Bones -- Metabolism -- Periodicals; Mineral metabolism -- Periodicals; 612.392
• DOI: 10.1002/jbmr.4294
• Languages: English
• ISSNs: 0884-0431

Abstract

ABSTRACT: Vertebral fractures are clinically important sequelae of a wide array of pediatric diseases. In this study, we examined the accuracy of case‐finding strategies for detecting incident vertebral fractures (IVF) over 2 years in glucocorticoid‐treated children ( n = 343) with leukemia, rheumatic disorders, or nephrotic syndrome. Two clinical situations were addressed: the prevalent vertebral fracture (PVF) scenario (when baseline PVF status was known), which assessed the utility of PVF and low lumbar spine bone mineral density (LS BMD; Z ‐score <−1.4), and the non‐PVF scenario (when PVF status was unknown), which evaluated low LS BMD and back pain. LS BMD was measured by dual‐energy X‐ray absorptiometry, vertebral fractures were quantified on spine radiographs using the modified Genant semiquantitative method, and back pain was assessed by patient report. Forty‐four patients (12.8%) had IVF. In the PVF scenario, both low LS BMD and PVF were significant predictors of IVF. Using PVF to determine which patients should have radiographs, 11% would undergo radiography (95% confidence interval [CI] 8–15) with 46% of IVF (95% CI 30–61) detected. Sensitivity would be higher with a strategy of PVF or low LS BMD at baseline (73%; 95% CI 57–85) but would require radiographs in 37% of children (95% CI 32–42). In the non‐PVF scenario, the strategy of low LS BMD and back pain produced the highest specificity of any non‐PVF model at 87% (95% CI 83–91), the greatest overall accuracy at 82% (95% CI 78–86), and the lowest radiography rate at 17% (95% CI 14–22). Low LS BMD or back pain in the non‐PVF scenario produced the highest sensitivity at 82% (95% CI 67–92), but required radiographs in 65% (95% CI 60–70). These results provide guidance for targeting spine radiography in children at risk for IVF. © 2021 American Society for Bone and Mineral Research (ASBMR).