Acidity‐Triggered Transformable Polypeptide Self‐Assembly to Initiate Tumor‐Specific Biomineralization (Adv. Mater. 15/2023). Issue 15 (13th April 2023)

• Record Type: Journal Article
• Authors: Liu, Yang; Jiang, Zhongyu; Tong, Shizheng; Sun, Yifu; Zhang, Yu; Zhang, Jiayuan; Zhao, Duoyi; Su, Yuanzhen; Ding, Jianxun; Chen, Xuesi
• Is Part Of: Advanced materials. Volume 35:Issue 15(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-04-13
• Subjects: acidity‐responsiveness -- biomineralization -- transformable polypeptide self‐assembly -- tumor blockade therapy -- tumor microenvironment regulation; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202370110
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Therapeutic Transformable Polypeptides In article number 2203291, Jianxun Ding, Xuesi Chen, and co‐workers report a therapeutic transformable polypeptide nanoparticle that initiates selective biomineralization for effective blockade therapy of osteosarcoma after activation by the acidic tumor microenvironment, through triggering continuous ion deposition to construct a mineralized barrier around the tumor and alleviate bone dissolution. The strategy indicates significant potential for clinical osteosarcoma therapy.