The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives. Issue 4 (6th March 2023)

• Record Type: Journal Article
• Authors: Yoshimura, Rikuya; Miyasaka, Tomohiro; Funamoto, Satoru; Saito, Takashi; Saido, Takaomi C.; Ikegawa, Masaya; Kakuda, Nobuto
• Is Part Of: Brain and behavior. Volume 13:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-06
• Subjects: Amyloid β protein -- Senile plaque; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.2953
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42. Abstract : This article showed suitable fixatives need to detect the form of senile plaque and its associated proteins in Alzheimer's disease model mice brains.