A decrease in newly diagnosed patients with adult T-cell leukemia/lymphoma in Kagoshima, a highly endemic area of HTLV-1 in southwestern Japan. Issue 4 (21st March 2023)

• Record Type: Journal Article
• Authors: Owatari, Satsuki; Tokunaga, Masahito; Nakamura, Daisuke; Uozumi, Kimiharu; Sagara, Yasuko; Nakamura, Hitomi; Haraguchi, Koichi; Nakano, Nobuaki; Yoshimitsu, Makoto; Ito, Yoshikiyo; Utsunomiya, Atae; Otsuka, Maki; Hanada, Shuichi; Iwanaga, Masako; Ishitsuka, Kenji
• Is Part Of: Leukemia & lymphoma. Volume 64:Issue 4(2023)
• Page Start: 865
• Page End: 873
• Publication Date: 2023-03-21
• Subjects: HTLV-1 -- seropositivity -- ATL -- incidence; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2023.2173524
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type-I (HTLV-1). This study investigated whether the number of newly diagnosed patients with ATL is decreasing in the background of a declining number of individuals infected by HTLV-1 in Kagoshima, Japan, one of the most endemic areas of HTLV-1 in the world. We retrospectively analyzed the number of newly diagnosed patients with ATL between January 2001 and December 2021 in three major hospitals. The number of newly diagnosed patients with B-cell non-Hodgkin lymphoma (B-NHL) in the same period was examined as an internal control. One thousand eighteen and 2, 029 patients with ATL and B-NHL were registered, respectively. The age-adjusted incidence of ATL steadily increased between 2001 and 2012, whereas that between 2013 and 2021 decreased. Despite the limitation of its retrospective nature, this is the first report indicating a decrease in ATL patients in Japan.