ACCELERATED PROGRESSION OF DIABETIC RETINOPATHY IN A PATIENT WITH ACQUIRED LIPODYSTROPHY AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION. Issue Volume 17:Issues 3(2023) (May 2023)

• Record Type: Journal Article
• Authors: Haruta, Masatoshi; Iwata, Kensaku; Yoshida, Shigeo
• Is Part Of: Retinal cases & brief reports. Volume 17:Issues 3(2023)
• Page Start: 321
• Page End: 323
• Publication Date: 2023-05
• Subjects: acute lymphocytic leukemia -- hypertriglyceridemia -- late complication -- lipemia retinalis -- metabolic abnormalities; Retina -- Diseases -- Periodicals; Retina -- Periodicals; Retinal Diseases -- Periodicals; Retina -- Case Reports; Retinal Diseases -- Case Reports; 617.7
• DOI: 10.1097/ICB.0000000000001180
• Languages: English
• ISSNs: 1935-1089

Abstract

Abstract : A 23-year-old woman with a diagnosis of acquired lipodystrophy after hematopoietic stem cell transplantation was referred for ophthalmic evaluation. Funduscopy revealed bilateral diabetic retinopathy and lipemia retinalis, neither of which was apparent 2 years earlier. Accelerated progression of diabetic retinopathy seemed to be associated with the onset of lipemia retinalis. Abstract : Purpose: To report a case of bilateral proliferative diabetic retinopathy and lipemia retinalis in a patient with acquired lipodystrophy. Methods: A retrospective case report. Results: A 23-year-old woman with a diagnosis of acquired lipodystrophy was referred for ophthalmic evaluation. She had been diagnosed with acute lymphocytic leukemia at the age of 3 years and undergone hematopoietic stem cell transplantation. Best-corrected visual acuity was 20/20 in both eyes; however, funduscopy revealed bilateral diabetic retinopathy and lipemia retinalis, neither of which was apparent 2 years earlier. She had a glycated hemoglobin level of 9.6% and a triglyceride level of 7, 394 mg/dL with creamy appearance of serum. Fluorescein angiography showed bilateral neovascularization. Conclusion: Accelerated progression of diabetic retinopathy in this case seemed to be associated with the onset of lipemia retinalis. We encourage continued ophthalmologic monitoring of patients who underwent hematopoietic stem cell transplantation in childhood for possible accelerated course of diabetic retinopathy.