Dysregulation of long non‐coding RNAs and their mechanisms in Huntington's disease. Issue 9 (24th May 2021)

• Record Type: Journal Article
• Authors: Tan, Xiaoping; Liu, Yang; Liu, Yan; Zhang, Taiming; Cong, Shuyan
• Is Part Of: Journal of neuroscience research. Volume 99:Issue 9(2021)
• Page Start: 2074
• Page End: 2090
• Publication Date: 2021-05-24
• Subjects: Huntington's disease -- lncRNA -- mHTT -- polyQ -- RNA; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.24825
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract: Extensive alterations in gene regulatory networks are a typical characteristic of Huntington's disease (HD); these include alterations in protein‐coding genes and poorly understood non‐coding RNAs (ncRNAs), which are associated with pathology caused by mutant huntingtin. Long non‐coding RNAs (lncRNAs) are an important class of ncRNAs involved in a variety of biological functions, including transcriptional regulation and post‐transcriptional modification of many targets, and likely contributed to the pathogenesis of HD. While a number of changes in lncRNAs expression have been observed in HD, little is currently known about their functions. Here, we discuss their possible mechanisms and molecular functions, with a particular focus on their roles in transcriptional regulation. These findings give us a better insight into HD pathogenesis and may provide new targets for the treatment of this neurodegenerative disease.