914. Epidemiology of Patients with ESKAPE Pathogen Bloodstream Infection in the US Military Health System. (31st December 2020)

• Record Type: Journal Article
• Authors: Vostal, Alexander C; Grance, Melissa; Chukwuma, Uzo; Morales, Carlos; Lanteri, Charlotte; Telu, Kalyani; Parmelee, Edward; Powers, John H; Mende, Katrin
• Is Part Of: Open forum infectious diseases. Volume 7:Number 1(2020) Supplement
• Page Start: S492
• Page End: S492
• Publication Date: 2020-12-31
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa439.1102
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Bloodstream infections (BSI) are associated with both inpatient mortality and substantial morbidity in the United States. We sought to characterize the epidemiology of BSIs with ESKAPE pathogens on patients served by the United States Military Healthcare System (MHS), which actively prospectively captures clinical and microbiological data from US service members and their beneficiaries. Methods: We performed a retrospective analysis of MHS patients with blood cultures positive for ESKAPE pathogens ( E. faecium, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, and Enterobacter spp. ), as well as Neisseria gonorrhoeae and Raoultella spp. between January 2010 and December 2015. Microbiological data from the Navy and Marine Core Public Health Center was retrospectively collated with clinical and demographic data from the MHS Data Repository. Results: We identified 7, 404 patients who experienced 8, 791 episodes of ESKAPE (including N. gonorrhoeae and Raoultella spp. ) BSI. The patients were predominately active duty (N=688) or retired (N=2, 517) Armed Forces service members and their dependents (N=2, 361). Further, 59.4% were male and 47.5% were >65 years old. A total of 5, 594 (75.5%) of BSI episodes were associated with hospital admission, with an average length of stay of 14.9 days (SD of 27.5 days) and 47.4% (N=2, 650) of those admissions were associated with an ICU stay averaging 8.6 days (SD of 18.0 days). The most common pathogens detected were E. coli (34.6%, N= 3, 042) followed by S. aureus (28.0%, N=2, 464), with 7.6% and 40.7% of isolates resistant to ceftriaxone and methicillin, respectively. We found a larger proportion of E. coli BSI in females (47.4% versus 26.2%) and S. aureus BSI in males (32% versus 21.9%). The frequency of A. baumannii BSI in younger patients, ages 18-30, was an average 4.5 fold higher than in older age groups (30-50, 50-65 and >65). Conclusion: We noted epidemiological differences in the burden of ESKAPE pathogen BSIs, in various populations including sex and age specific risk factors in a population served by the MHS. Further work is underway to evaluate risk factors for infection and outcomes with pathogens with in vitro resistance controlling for factors such as age, gender, co-morbid diseases and severity of illness. Disclosures: All Authors : No reported disclosures