Exploration of the relationships between clinical traits and functional connectivity based on surface morphology abnormalities in bulimia nervosa. Issue 4 (15th March 2023)

• Record Type: Journal Article
• Authors: Li, Weihua; Wang, Miao; Wu, Guowei; Wang, Jiani; Li, Xiaohong; Yang, Zemei; Chen, Qian; Yang, Zhenghan; Li, Zhanjiang; Zhang, Peng; Tang, Lirong; Wang, Zhenchang
• Is Part Of: Brain and behavior. Volume 13:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-15
• Subjects: eating disorders -- surface‐based functional connectivity -- surface‐based morphometry; Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.2930
• Languages: English
• ISSNs: 2162-3279

Abstract

Abstract: Background: Bulimia nervosa is a recurrent eating disorder with uncertain pathogenesis. Recently, there has been growing interest in using neuroimaging techniques to explore brain structural and functional alterations in bulimia nervosa, but the findings of previous studies have a great number of inconsistencies. Methods: Here, we collected anatomical and resting‐state functional magnetic resonance imaging data from 43 bulimia nervosa patients and 34 matched healthy controls (HCs). We applied a surface‐based morphology analysis to explore brain cortical morphology differences and a novel surface‐based functional connectivity (FC) analysis to investigate functional abnormalities. Principal component analysis was performed to analyze the behavioral data of the participants. We further analyzed the relationships between abnormalities in cortical characteristics or FC and clinical features. Results: We observed increased greater sulcal depth in the right superior temporal gyrus (STG) and the right medial orbitofrontal cortex (mOFC) in bulimia nervosa patients than in the HCs. Additionally, the patients exhibited increased FC between the right STG and right ventral tegmental area but decreased function between the right mOFC and right putamen, which was significantly negatively correlated with the first principal component reflecting the severity of bulimia nervosa symptom. Conclusions: Our findings provide evidence of neuroanatomical and functional abnormalities in bulimia nervosa patients. Moreover, the FC between the right mOFC and right putamen was associated with symptom severity of bulimia nervosa, which may be a neural marker and involved in the neuropathological mechanism of bulimia nervosa. Abstract : We conducted a novel surface‐based FC analysis based on surface morphology alterations in BN, PCA to analyze the behavioral data of the participants and further explored the relationships between neuroimaging findings and principal component. Altered FC based on surface morphology alterations was related with related to the severity of BN symptom. Our findings provided further evidence that reward processing and body image processing may be involved in BN.