In Situ Structure Transformation of a Sprayed Gel for pH‐Ultrasensitive Nano‐Catalytic Antibacterial Therapy. Issue 10 (15th January 2023)

• Record Type: Journal Article
• Authors: Niu, Zhihui; Xie, Mingxiao; Wei, Zicheng; Guo, Yang; Han, Mengxuan; Ding, Yingying; Huang, Jianyu; Zheng, Kang; Zhang, Yao; Song, Yuanda; Niu, Dechao; Li, Yongsheng; Wen, Guangwu; Li, Xiaowei; Shi, Jianlin
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-15
• Subjects: bacterial infection treatment -- nano‐catalytic therapy -- pH‐ultrasensitivity -- sprayed gels -- structure transformation; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202441
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Nano‐catalytic bacterial killing provides new opportunities to address ever‐increasing antibiotic resistance. However, the intrinsic catalytic activity usually depends on a much lower pH conditions (pH = 2–5) than that in the weakly acidic bacterial microenvironments (pH = 6–7) for reactive oxygen species production by Fenton reactions. Herein, a MnSiO3 ‐based pH‐ultrasensitive "in situ structure transformation" is first reported to significantly promote the adhesion between material and bacteria, and shorten the diffusion distance (<20 nm) to compensate ultra‐short life (<200 ns) of ·OH generated by Mn 2+ ‐mediated Fenton‐like reaction, finally enhancing its nano‐catalytic antibacterial performance in weakly acidic conditions. A separated spray bottle is further designed to achieve in situ gelation at the wound site, which demonstrates excellent shape adaptability to complicated and rough surfaces of wounds, allowing for long‐term nano‐catalyst release. As a result, bacterial‐infected wound healing is efficiently promoted. Herein, the in situ sprayed nano‐catalytic antibacterial gel presents a promising paradigm for bacterial infection treatment. Abstract : MnSiO3 ‐based "in situ structure transformation" strategy is introduced to design a sprayed gel for pH‐ultrasensitive nano‐catalytic antibacterial therapy, which demonstrates high antibacterial efficacy in the very weakly acidic bacterial microenvironment and excellent shape adaptability to complicated and rough surface of wounds, allowing for long‐term nano‐catalyst release and efficiently promoting bacterial‐infected wound healing with high biocompatibility.