Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R. Issue 12 (28th September 2021)

• Record Type: Journal Article
• Authors: De Simone, Marco; Chirichella, Michele; Emming, Stefan; Mazzara, Saveria; Ranzani, Valeria; Gruarin, Paola; Moschetti, Giorgia; Pulvirenti, Nadia; Maglie, Stefano; Vasco, Chiara; Crosti, Maria Cristina; Rossetti, Grazisa; Pagani, Massimiliano; Abrignani, Sergio; Monticelli, Silvia; Geginat, Jens
• Is Part Of: European journal of immunology. Volume 51:Issue 12(2021)
• Page Start: 3243
• Page End: 3246
• Publication Date: 2021-09-28
• Subjects: Tr1‐like cells -- microRNAs -- EOMES -- IL‐10R; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202149315
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : Ex vivo gene expression and miRNA profiling of Eomes + Tr1‐like cells suggested that they represent a differentiation stage that is intermediate between Th1‐cells and cytotoxic CD4 + T‐cells. Several microRNAs were downregulated in Eomes + Tr1‐like cells that might inhibit Tr1‐cell differentiation. In particular, miR‐92a targeted Eomes, while miR‐125a inhibited IFN‐g and IL‐10R expression.