Intraluminal oxygen mitigates acute mesenteric ischaemia: a systematic review of methods and outcomes in animal studies. Issue 4 (20th December 2022)

• Record Type: Journal Article
• Authors: Joh, Daniel; Morreau, Mathew; Lee, Angela; Pendharkar, Sayali; Stokes, Bruce; Warren, Roger; Hickey, Anthony; Phillips, Anthony J.; Windsor, John A
• Is Part Of: ANZ journal of surgery. Volume 93:Issue 4(2023)
• Page Start: 859
• Page End: 868
• Publication Date: 2022-12-20
• Subjects: acute and critical illness -- emergency general surgery -- mesenteric ischaemia -- non‐occlusive mesenteric ischaemia; Surgery -- Periodicals; 617.005
• DOI: 10.1111/ans.18211
• Languages: English
• ISSNs: 1445-1433

Abstract

Abstract: Background: Acute Mesenteric Ischaemic (AMI) is a rare condition with significant morbidity and mortality. Many causes of AMI exist, which usually begin with mucosal injury. Onset is insiduous and there is frequent diagnostic delay. Current treatments can only control established injury and prevent propagation, hence new interventions are needed. The prevention and treatment of AMI by intraluminal delivery of oxygen has yet to be investigated in the clinical setting. This article aims to systemically review experimental studies investigating this novel therapy. Methods: Following the PRISMA guidelines, searches of PubMed and Ovid MEDLINE databases were performed up to June 2022. Two independent investigators extracted the data. Results: There were 20 experimental studies, 16 of which used an occlusive ischaemia reperfusion model. Six different formulations were used to deliver intraluminal oxygen, with perflurocarbon being the most common. Studies consistently showed local and systemic benefits. Intraluminal oxygen therapy improved histological severity of mucosal injury in all studies when oxygen was delivered during the ischaemia phase, but could cause harm if given during the reperfusion phase. Improvement was also demonstrated in endpoints assessing intestinal function, biomarkers of intestinal damage, measures of systemic physiological derangement and mortality. Conclusion: Intraluminal oxygenation appears to be an effective treatment for AMI. There remain significant questions regarding optimal timing and delivery formulation before clinical translation of this treatment strategy. Abstract : A systematic review of pre‐clinical evidence for intraluminal oxygenation in the treatment of intestinal ischaemia. The majority of studies demonstrated a significant benefit. There remain important questions regarding the optimal timing and delivery technique before clinical translation of this treatment strategy.