Changes in brain metabolites and resting‐state connectivity in collegiate basketball players as a function of play time. Issue 6 (19th July 2021)

• Record Type: Journal Article
• Authors: Sung, Dongsuk; Smith, Jeremy L.; Yarabarla, Suma; Prasad, Ojaswa; Owusu‐Ansah, Maame; Ekici, Selin; Allen, Jason W.; Mines, Brandon; Fleischer, Candace C.
• Is Part Of: Journal of neuroimaging. Volume 31:Issue 6(2021)
• Page Start: 1146
• Page End: 1155
• Publication Date: 2021-07-19
• Subjects: brain metabolites -- magnetic resonance spectroscopy -- resting‐state MRI -- sports‐related brain injury; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12909
• Languages: English
• ISSNs: 1051-2284

Abstract

ABSTRACT: Background and Purpose: Magnetic resonance (MR) biomarkers are emerging for sports‐related traumatic brain injury (TBI), but the effect of play time has not been characterized. Our goal was to characterize brain and inflammatory marker changes as a function of play time. Methods: Nine male players (21±2 years old) from a single collegiate basketball team were included. MR imaging (MRI), MR spectroscopy, and plasma were collected pre, mid, and postseason. Game time played was calculated for each subject. Changes in brain volume, diffusion tensor imaging (DTI), metabolites (normalized to total creatine, tCr), temperature, structural and functional connectivity, and inflammatory markers were quantified. Results: Myo‐inositol/tCr in the left frontal white matter and brain temperature in the left frontal lobe varied significantly between time points. Glutamate (Glu/tCr) in the right frontal white matter and N ‐acetylaspartate in the posterior cingulate cortex (PCC) were negatively associated with minutes played. Midseason play time was associated with stronger blood‐oxygen‐level‐dependent correlations between PCC and occipital areas, and weaker correlations between PCC and superior frontal connectivity. PCC Glu/tCr was positively associated with connectivity between the PCC and posterior supramarginal gyrus at preseason and with connectivity across time points among several right hemisphere regions. Volume, DTI, and inflammatory markers did not vary significantly. Conclusion: Given that MR parameters vary with game play time in the absence of diagnosed injury, play time should be considered as a factor in sports‐related TBI research.