Population‐based study of multisystem inflammatory syndrome associated with COVID‐19 found that 36% of children had persistent symptoms. (1st December 2021)

• Record Type: Journal Article
• Authors: Kahn, Robin; Berg, Stefan; Berntson, Lillemor; Berthold, Elisabet; Brodin, Petter; Bäckström, Fredrik; Compagno, Michele; Fasth, Anders; Lingman Framme, Jenny; Horne, AnnaCarin; Hätting, Josefin; Król, Petra; Kukka, Antti J; Mossberg, Maria; Månsson, Bengt; Nordenhäll, Charlotta; Idring Nordström, Selma; Khammari Nyström, Fatine; Palmblad, Karin; Rasti, Reza; Rudolph, André; Rydenman, Karin; Sundberg, Erik; Säve‐Söderbergh, Eva; Altman, Maria
• Is Part Of: Acta pædiatrica. Volume 111:Number 2(2022)
• Page Start: 354
• Page End: 362
• Publication Date: 2021-12-01
• Subjects: abnormal echocardiograms -- fatigue -- intensive care -- outcomes -- persistent symptoms; Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.16191
• Languages: English
• ISSNs: 0803-5253

Abstract

Abstract: Aim: Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS‐C) associated with COVID‐19. Methods: This national, population‐based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS‐C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow‐up protocols are suggested. Results: We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS‐C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results. Conclusion: More than a third (36%) of the patients had persistent symptoms 8 weeks after MIS‐C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow‐up visits are important after MIS‐C.