Association between insomnia and the incidence of myocardial infarction: A systematic review and meta‐analysis. Issue 4 (25th February 2023)

• Record Type: Journal Article
• Authors: Dean, Yomna E.; Shebl, Mohamed A.; Rouzan, Samah S.; Bamousa, Bdoor Ahmed A; Talat, Nesreen Elsayed; Ansari, Sana Afreen; Tanas, Yousef; Aslam, Muaaz; Gebril, Sara; Sbitli, Taher; Eweis, Ramy; Shahid, Rameen; Salem, Amr; Abdelaziz, Heba Ahmed; Shah, Jaffer; Hasan, Walaa; Hakim, Diaa; Aiash, Hani
• Is Part Of: Clinical cardiology. Volume 46:Issue 4(2023)
• Page Start: 376
• Page End: 385
• Publication Date: 2023-02-25
• Subjects: insomnia -- myocardial infarction -- sleep disorders -- STEMI; Cardiology -- Periodicals; 616.12005
• DOI: 10.1002/clc.23984
• Languages: English
• ISSNs: 0160-9289

Abstract

Abstract: Background: Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods: PubMed, Scopus, and Web of Science were searched using terms; such as "Insomnia" and "MI." Only observational controlled studies with data on the incidence of MI among insomniacs were included. Revman software version 5.4 was used for the analysis. Results: Our pooled analysis showed a significant association between insomnia and the incidence of MI compared with noninsomniacs (relative risk [RR] = 1.69, 95% confidence interval [CI] = 1.41–2.02, p < .00001). Per sleep duration, we detected the highest association between ≤5 h of sleep, and MI incidence compared to 7−8 h of sleep (RR = 1.56, 95% CI = 1.41–1.73). Disorders of initiating and maintaining sleep were associated with increased MI incidence (RR = 1.13, 95% CI = 1.04–1.23, p = .003). However, subgroup analysis of nonrestorative sleep and daytime dysfunction showed an insignificant association with MI among both groups (RR = 1.06, 95% CI = 0.91–1.23, p = .46). Analysis of age, follow‐up duration, sex, and comorbidities showed a significant association in insomniacs. Conclusion: Insomnia and ≤5 h of sleep are highly associated with increased incidence of MI; an association comparable to that of other MI risk factors and as such, it should be considered as a risk factor for MI and to be incorporated into MI prevention guidelines. Abstract :